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Started by SR
Posted: January 29, 2012 at 21:36
Hi there. I've just been diagnosed with mrsa-pvl. Does anybody here
have any experience of this? I am led to believe its more known in the
US than the UK where I am.

Thanks SR xx
Re: Mrsa-Pvl
Reply #1 by ruth
Posted: January 29, 2012 at 22:26
Infections caused by community-acquired methicillin-resistant Staphylococcus aureus
(CA-MRSA) have emerged as a major public health problem worldwide. CA-MRSA
producing Panton-Valentine leukocidin (PVL) causes mostly skin and soft tissue
infections, but it can also cause severe invasive disease, including necrotizing

All patients were successfully treated with clindamycin or trimethoprim-
sulfamethoxazole in combination with rifampin. Nasal carriage was suppressed with
intranasal application of mupirocin, but three months later recolonisation with the
same t008, PVL positive strain occurred in one patient.

Wiese-Posselt et al. described a successful termination of a large furunculosis
outbreak due to PVL lukS-lukF–positive S. aureus by decolonisation strategy, including
mupirocin nasal ointment and disinfecting wash solution.

Seven weeks after decolonisation, the authors reported a recolonisation in two persons.
These two patients received a 10-day course with rifampin and trimethoprim-
sulfamethoxazole and decolonisation procedures were repeated. Twenty weeks after
the initial decolonisation, no PVL lukS-lukF–positive strains were detected.
Re: Mrsa-Pvl
Reply #2 by SR
Posted: January 29, 2012 at 22:44
Thanks for the info. I should be starting the decolonisation treatment
this week. The doctors don't seem to know much about the pvl and have
passed me on to the health board to be dealt with. I feel very much
left in the dark.
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